Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study.
Vinicius Rio Verde Melo MunizFábio Daumas NunesFlávia Caló de Aquino XavierMaria Cristina Teixeira CangussuRoseana de Almeida FreitasPatrícia Ramos CuryClarissa Araújo GurgelJean Nunes Dos SantosPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)
This study provided insights into the activation of the HH signaling pathway in CGCG. In addition, the activation of this pathway (SHH and GLI1) might play some role in the differentiation of stromal myofibroblasts, although these markers including Cyclin D1 and SMA do not indicate aggressiveness of the CGCG. Furthermore, this myofibroblastic differentiation process would occur at the expense of maturation of these lesions.