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Protective Variants in Alzheimer's Disease.

Shea J AndrewsBrian Fulton-HowardAlison Goate
Published in: Current genetic medicine reports (2019)
There are very few protective variants with functional evidence and a derived allele with a frequency below 20%. Additional fine mapping and multi-omic studies are needed to further validate and characterize known variants as well as specialized genome-wide scans to identify novel variants.
Keyphrases
  • copy number
  • genome wide
  • dna methylation
  • computed tomography
  • high resolution
  • palliative care
  • gene expression
  • magnetic resonance
  • mild cognitive impairment
  • contrast enhanced
  • high density
  • case control