Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic, and Antimicrobial Study.
Aniruddha AdhikariSubham DasguptaSayan BayanSusmita MondalRia GhoshSoumendra DarbarTanusri Saha-DasguptaSamit Kumar RaySamir Kumar PalPublished in: ACS applied bio materials (2021)
Centers for Disease Control and Prevention (CDC) warns the use of one-way valves or vents in face masks for potential threat of spreading COVID-19 through expelled respiratory droplets. Here, we have developed a nanoceutical cotton fabric duly sensitized with non-toxic zinc oxide nanomaterial for potential use as a membrane filter in the one-way valve for the ease of breathing without the threat of COVID-19 spreading. A detailed computational study revealed that zinc oxide nanoflowers (ZnO NFs) with almost two-dimensional petals trap SARS-CoV-2 spike proteins, responsible to attach to ACE-2 receptors in human lung epithelial cells. The study also confirmed significant denaturation of the spike proteins on the ZnO surface, revealing removal of the virus upon efficient trapping. Following the computational study, we have synthesized ZnO NF on a cotton matrix using a hydrothermal-assisted strategy. Electron-microscopic, steady-state, and picosecond-resolved spectroscopic studies confirm attachment of ZnO NF to the cotton (i.e., cellulose) matrix at the atomic level to develop the nanoceutical fabric. A detailed antimicrobial assay using Pseudomonas aeruginosa bacteria (model SARS-CoV-2 mimic) reveals excellent antimicrobial efficiency of the developed nanoceutical fabric. To our understanding, the nanoceutical fabric used in the one-way valve of a face mask would be the choice to assure breathing comfort along with source control of COVID-19 infection. The developed nanosensitized cloth can also be used as an antibacterial/anti CoV-2 washable dress material in general.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- aortic valve
- staphylococcus aureus
- pseudomonas aeruginosa
- room temperature
- quantum dots
- reduced graphene oxide
- signaling pathway
- mitral valve
- oxide nanoparticles
- oxidative stress
- lps induced
- heart failure
- biofilm formation
- multidrug resistant
- heavy metals
- human health
- risk assessment
- aortic stenosis
- transcatheter aortic valve implantation
- single cell
- ejection fraction