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Are We There Yet? Intracellular Sensing with Luminescent Nanoparticles and FRET.

W Russ AlgarAgnes SzwarczewskiMelissa Massey
Published in: Analytical chemistry (2023)
Combinations of luminescent nanoparticles (LNPs) and Förster resonance energy transfer (FRET) offer properties and features that are advantageous for sensing of biomolecular targets and activity. Despite a multitude of designs for LNP-FRET sensors, intracellular sensing applications are underdeveloped. We introduce readers to this field, summarize essential concepts, meta-analyze the literature, and offer a perspective on the bottleneck in LNP-FRET sensor development.
Keyphrases
  • energy transfer
  • quantum dots
  • systematic review
  • single molecule
  • sensitive detection