Lower intensity therapy with cladribine/low dose cytarabine/venetoclax in older patients with acute myeloid leukemia compares favorably with intensive chemotherapy among patients undergoing allogeneic stem cell transplantation.
Jayastu SenapatiHagop M KantarjianAlexandre BazinetPatrick K RevilleNicholas James ShortNaval G DaverGautam BorthakurAlex BatallerElias J JabbourCourtney D D DiNardoFady Gh HaddadKoiji SasakiUday R PopatBetül OranAmin M AlousiSanam LoghaviElizabeth ShpallGuillermo Garcia ManeroFarhad RavandiTapan Mahendra KadiaPublished in: Cancer (2024)
In conclusion, treatment with CLAD/LDAC/Ven was associated with favorable outcomes in older patients who underwent subsequent allogeneic SCT. The OS was comparable to that with intensive chemotherapy followed by allogeneic SCT, but the CIR rate was significantly lower.
Keyphrases
- stem cell transplantation
- high dose
- low dose
- acute myeloid leukemia
- patients undergoing
- locally advanced
- allogeneic hematopoietic stem cell transplantation
- physical activity
- middle aged
- high intensity
- type diabetes
- bone marrow
- chemotherapy induced
- radiation therapy
- chronic lymphocytic leukemia
- adipose tissue
- replacement therapy
- skeletal muscle