Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling.
Stacey L KigarMary-Ellen LynallAllison E DePuytRobert AtkinsonVirginia H SunJoshua D SamuelsNicole E EassaChelsie N PoffenbergerMichael L LehmannSamuel J ListwakFerenc LivakAbdel G ElkahlounMenna R ClatworthyEdward T BullmoreMiles HerkenhamPublished in: bioRxiv : the preprint server for biology (2024)
Type I interferon sensing neutrophils accumulate in meninges of psychosocially stressed mice via skull bone marrow channels and are associated with the negative behavioral sequelae of stress; blockade of this pathway inhibits neutrophil trafficking and improves behavioral outcomes.