Percutaneous CT-Guided Bone Lesion Biopsy for Confirmation of Bone Metastases in Patients with Breast Cancer.
Lucija KovacevicMislav CavkaZlatko MarusicElvira KresicAndrija StajduharLora GrbanovicIvo Dumic-CuleMaja PrutkiPublished in: Diagnostics (Basel, Switzerland) (2022)
We aimed to determine diagnostic accuracy of CT-guided bone lesion biopsy for the confirmation of bone metastases in patients with breast cancer and assessment of hormone receptor status in metastatic tissue. A total of 56 female patients with breast cancer that underwent CT-guided biopsy of suspected bone metastasis were enrolled in this retrospective study. Three different techniques were employed to obtain samples from various sites of skeleton. Collectively, 11 true negative and 3 false negative findings were revealed. The sensitivity of CT-guided biopsy for diagnosing bone metastases was 93.6%, specificity was 100% and accuracy was 94.8%. Discordance in progesterone receptor status and complete concordance in estrogen receptor status was observed. Based on our single-center experience, bone metastasis biopsy should be routinely performed in patients with breast cancer and suspicious bone lesions, due to the impact on further treatment.
Keyphrases
- ultrasound guided
- bone mineral density
- fine needle aspiration
- estrogen receptor
- image quality
- computed tomography
- dual energy
- bone loss
- soft tissue
- contrast enhanced
- bone regeneration
- positron emission tomography
- squamous cell carcinoma
- small cell lung cancer
- postmenopausal women
- magnetic resonance imaging
- pulmonary embolism
- pet ct