Maternal IL-10 restricts fetal emergency myelopoiesis.

Amelie Collins James W Swann Melissa A Proven Chandani M Patel Carl A Mitchell Monica Kasbekar Paul V Dellorusso Emmanuelle Passegue

Published in: bioRxiv : the preprint server for biology (2023)

Fetal hematopoietic stem and progenitor cells are restricted from activating emergency myelopoiesis pathways by maternal IL-10, resulting in inadequate myeloid cell production in response to inflammatory challenges and contributing to neonatal neutropenia.

Keyphrases

public health
emergency department
birth weight
pregnancy outcomes
healthcare
single cell
signaling pathway
dendritic cells
oxidative stress
bone marrow
cell therapy
acute myeloid leukemia
emergency medical
weight gain
stem cells
preterm birth