Regulatory B cells with IL-35 and IL-10 expression in a normal and abortion-prone murine pregnancy model.

Anna Slawek Daria LorekAnna Ewa KedzierskaAnna Chelmonska-Soyta

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

We indicated that the early stages of abortion-prone pregnancy (3 dpc) in mice were characterized by diminished frequency of B cells producing IL-35 at both local and peripheral levels. These results and the observed lower level of IL-35 in women suffering from recurrent spontaneous abortion suggest that IL-35 may be involved in the maintenance of pregnancy.

Keyphrases

pregnancy outcomes
preterm birth
type diabetes
transcription factor
polycystic ovary syndrome
pregnant women
adipose tissue
high fat diet induced
wild type