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[Rare differential diagnosis of an osteolytic lesion of the mandible in a young adult].

Hyunkyu ShinAndreas NarosSinja KieningerJoachim PolligkeitFalko FendJakob Milla
Published in: Pathologie (Heidelberg, Germany) (2024)
We report a rarely occurring hematologic neoplasm in a young adult. Hematologic neoplasms were first described in 2008 and are now included in both accepted tumor classification systems, i.e., International Consensus Classification and World Health Organization. This hematologic neoplasm shows a characteristic ALK positivity in immunohistochemical examination and correspondingly, ALK fusion genes in the molecular analysis. Pathologists should be aware of this entity, particularly as it is challenging to differentiate from other more frequent neoplasms of the same disease group or mesenchymal neoplasm with ALK aberration.
Keyphrases
  • young adults
  • low grade
  • advanced non small cell lung cancer
  • deep learning
  • machine learning
  • childhood cancer
  • stem cells
  • bone marrow
  • high grade
  • genome wide
  • gene expression
  • bioinformatics analysis