Brain Peri-Hematomal Area, a Strategic Interface for Blood Clearance: A Human Neuropathological and Transcriptomic Study.

Laurent Puy Romain PerbetMartin FigeacBelinda Duchêne Vincent Deramecourt Charlotte Cordonnier Vincent Bérézowski

Published in: Stroke (2022)

We provide histological and transcriptomic-based evidence in humans for the key role of peri-hematomal area in endogenous blood clearance process through the CD163/HO-1 pathway, especially from day 8 after ICH and favored by an anti-inflammatory environment. Our findings contribute to identify innovative therapeutic strategies for ICH.

Keyphrases

anti inflammatory
single cell
endothelial cells
rna seq
white matter
multiple sclerosis
signaling pathway
pi k akt
subarachnoid hemorrhage