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Structure and Microbiological Activity of 1 H -benzo[ d ]imidazole Derivatives.

Andrzej OlczakTomasz PawlakSylwia KałużyńskaKatarzyna GobisIzabela Korona-GłowniakKatarzyna SuśniakMarcin ZaborowskiMałgorzata Szczesio
Published in: International journal of molecular sciences (2023)
Three new crystal structures of 1 H -benzo[ d ]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vitro antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, as well as antifungal activity, by checking their selectivity. ADME calculations indicate that the compounds can be tested as potential drugs.
Keyphrases
  • solid state
  • high resolution
  • magnetic resonance
  • molecular docking
  • gram negative
  • molecular dynamics
  • molecular dynamics simulations
  • quality improvement
  • mass spectrometry
  • human health
  • climate change
  • drug induced