Safe and Scalable Syntheses of N , N -Dimethyltrifluoromethanesulfonamide (DMTMSA) and Other Trifluoromethanesulfonamide Solvents for High Energy Density Battery Applications.

A simple, scalable synthetic methodology for the synthesis of N , N -dimethyltrifluoromethanesulfonamide (DMTMSA) and other trifluoromethanesulfonamide solvents is described. No specialized glassware is required, water is the solvent, and an ice bath is used for cooling. Up to 155 g of DMTMSA is synthesized in a single batch in 92% yield. The optimized process is highly mass efficient (PMI = 9.1), and excess dimethylamine may be recovered (93% recovery, 51% decrease in waste) and recycled via a simple short-path distillation.