Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019.

Anton S M DofferhoffIanthe PiscaerLeon J SchurgersMargot P J VisserJody M W van den OuwelandPim A de JongReinoud GosensTilman M HackengHenny van DaalPetra LuxCecile MaassenEsther G A KarssemeijerCees VermeerEmiel F M WoutersLoes E M KistemakerJona WalkRob Janssen

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

dp-ucMGP was severely increased in COVID-19 patients, indicating extrahepatic vitamin K insufficiency, which was related to poor outcome; hepatic procoagulant factor II remained unaffected. These data suggest pneumonia-induced extrahepatic vitamin K depletion leading to accelerated elastic fiber damage and thrombosis in severe COVID-19 due to impaired activation of MGP and endothelial protein S, respectively.

Keyphrases

coronavirus disease
sars cov
drug induced
early onset
risk factors
respiratory syndrome coronavirus
high glucose
endothelial cells
diabetic rats
oxidative stress
electronic health record
big data
intensive care unit
machine learning
artificial intelligence
data analysis