Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.

Sandra M GonzalezWbeimar Aguilar-JimenezEdison Trujillo-GilWildeman Zapata-BuilesRuey-Chyi SuT Blake BallMaria T Rugeles

Published in: PloS one (2019)

Our in vitro findings suggest that VitD treatment could reduce HIV-1 transmission through a specific modulation of the activation levels and function of T cells, and the production of antiviral factors. In conclusion, VitD remains as an interesting potential strategy to prevent HIV-1 transmission that should be further explored.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hepatitis c virus
hiv testing
men who have sex with men
combination therapy
risk assessment
smoking cessation