Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice.

Our results indicate that film-restraint stress has more pronounced effects on body weight, depression-related behavior, and corticosterone response than tube-restraint stress in mice. These findings may help guide which restraint stress procedures to use, depending on the objectives of a given study, in generating animal models of stress-induced neuropsychiatric disorders.