A Dual Concentration-Tailored Cytokine-Chemo Nanosystem to Alleviate Multidrug Resistance and Redirect Balance of Cancer Proliferation and Apoptosis.
Yu HsiaMaharajan SivasubramanianChia-Hui ChuYao-Chen ChuangYiu-Kay LaiLeu-Wei LoPublished in: International journal of nanomedicine (2023)
We hereby develop and demonstrate a multifunctional MSN-Dox-TNFα system with concentration-tailored TNFα that can abrogate the drug resistance mechanism, and significantly inhibit the tumor growth through both intrinsic and extrinsic apoptosis pathways, thus making it a highly potential nanomedicine translated in the treatment of MDR tumors.
Keyphrases
- cancer therapy
- oxidative stress
- endoplasmic reticulum stress
- cell cycle arrest
- rheumatoid arthritis
- cell death
- papillary thyroid
- drug delivery
- smoking cessation
- combination therapy
- signaling pathway
- photodynamic therapy
- squamous cell
- pi k akt
- squamous cell carcinoma
- cell proliferation
- lymph node metastasis
- climate change