A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain.

Maria MaiarùRichard J ActonEva L WoźniakCharles A MeinChristopher G Bell Sandrine M Géranton

Published in: Clinical epigenetics (2023)

Overall, our data demonstrate that the Fkbp5 promoter DNAm landscape brings novel insight into the differing pathogenic origins of chronic pain, may be able to stratify patients and predict the susceptibility to chronic pain.

Keyphrases

chronic pain
dna methylation
pain management
end stage renal disease
genome wide
ejection fraction
gene expression
newly diagnosed
chronic kidney disease
prognostic factors
copy number
transcription factor
big data
machine learning
patient reported outcomes
deep learning
artificial intelligence
heat stress