Smoking Status at Diagnosis and Colorectal Cancer Prognosis According to Tumor Lymphocytic Reaction.
Kenji FujiyoshiYilin LiKoichiro HarukiTomotaka UgaiJunko KishikawaTsuyoshi HamadaLi LiuKota ArimaJennifer BorowskyJuha P VäyrynenMelissa ZhaoMai Chan LauSimeng GuShanshan ShiNaohiko AkimotoTyler S TwomblyDavid A DrewMingyang SongAndrew T ChanEdward L GiovannucciJeffrey A MeyerhardtCharles S FuchsReiko NishiharaJochen K LennerzMarios GiannakisJonathan A NowakXuehong ZhangKana WuShuji OginoPublished in: JNCI cancer spectrum (2020)
The association of smoking status at diagnosis with colorectal cancer mortality may be stronger for carcinomas with negative or low TIL, suggesting a potential interplay of smoking and lymphocytic reaction in the colorectal cancer microenvironment.