Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease.
Jonas K F JakobssonH Laura AaltonenHanna NicklassonAnders GudmundssonJenny RisslerPer WollmerJakob LöndahlPublished in: BMC pulmonary medicine (2018)
Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs. As expected, deposition increases for smaller particles and deeper inhalation. The observed results have implications for exposure assessment of air pollution and dosimetry of aerosol-based drug delivery of nanoparticles.