Epigenome-wide association study in healthy individuals identifies significant associations with DNA methylation and PBMC extract VEGF-A concentration.

Vesna GorenjakDwaine R VanceSébastien DadeMaria G StathopoulouLauren DohertyTing XieHelena MurrayChristine MassonJohn LamontPeter FitzgeraldSophie Siest

Published in: Clinical epigenetics (2020)

This study exposed twenty significant CpG sites linking DNA methylation to VEGF-A concentration. Methylation detected in promoter regions, such as TPX2 and HAS-1, could explain previously reported associations with the VEGFA gene. Methylation may also help in the understanding of the regulatory mechanisms of other genes located in the vicinity of detected CpG sites.

Keyphrases

dna methylation
genome wide
gene expression
copy number
vascular endothelial growth factor
endothelial cells
oxidative stress
transcription factor
genome wide identification