Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis.

Dan ShaoWenxiang ShenYuyang MiaoZhen GaoMenghao PanQiang WeiZuoting YanXiaoe ZhaoBaohua Ma

Published in: Journal of animal science and biotechnology (2023)

These results indicate that the natural compound SFN has a preventive effect on LPS-induced inflammation through by regulating the Nrf2-mediated autophagy pathway in primary goat mammary epithelial cells and a mouse model of mastitis, which may improve prevention strategies for mastitis in dairy goats.

Keyphrases

lps induced
oxidative stress
mouse model
inflammatory response
cell death
endoplasmic reticulum stress
signaling pathway