Rapid Virologic Response to Brincidofovir in Children with Disseminated Adenovirus Infection.

Shuk Ying ChanSusan E ProckopFarid BouladGenovefa A Papanicolaou Yeon Joo Lee

Published in: Infection & chemotherapy (2020)

Disseminated adenovirus infections (d-ADV) after hematopoietic cell transplant (HCT) are often fatal with limited treatment options. Brincidofovir (BCV) a lipid ester of cidofovir is developed for this indication. We report four pediatric HCT recipients with d-ADV treated successfully with BCV.

Keyphrases

cell cycle arrest
gene therapy
single cell
young adults
bone marrow
cell therapy
hiv infected
antiretroviral therapy
cell death
stem cells
loop mediated isothermal amplification