Association between 14 bp insertion/deletion HLA-G functional polymorphism and insulin resistance in a cohort of Italian children with obesity.

Pierluigi MarzuilloGiulia BelliniFrancesca PunzoAnna Di SessaStefano GuarinoGiuseppina R UmanoRoberto ToraldoEmanuele Miraglia Del GiudiceFrancesca Rossi

Published in: Pediatric diabetes (2018)

We showed a strong association between HLA-G 14 bp ins/ins genotype and HOMA in obese children and adolescents. This association could be hypothetically modulated by subclinical inflammation.

Keyphrases

weight loss
metabolic syndrome
type diabetes
insulin resistance
oxidative stress
adipose tissue
young adults
bariatric surgery
weight gain
high fat diet induced
obese patients
body mass index
physical activity
skeletal muscle