Synthesis and Antitumor Activity of Some New N 1-(8-fluoro-4-oxoquinolin-5-yl)amidrazones.

Hind M A YahyaJalal A ZahraSalim S SabriMustafa M El-AbadelahSanaa Bardaweel

Published in: Current organic synthesis (2024)

This study led to the successful synthesis of novel N1-(8-fluoro-4-oxoquinolin-5- yl)amidrazones. All the examined compounds showed moderate activity with reasonable IC50 values in the micromolar range compared to Doxorubicin.

Keyphrases

positron emission tomography
drug delivery
computed tomography
high intensity