Patients died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus.
Paola LeoneYaiza M ArenasTiziano BalzanoGergana MinchevaMar Martinez-GarciaCarmina MontoliuMarta LlansolaVicente FelipoPublished in: European journal of neurology (2023)
Patients with steatohepatitis show glial activation, immune cells infiltration, apoptosis and neuronal loss. Glial activation and neuronal loss remain in cirrhotic patients. This may explain the irreversibility of some cognitive alterations in hepatic encephalopathy. Cognitive reserve may contribute to different grades of cognitive impairment in spite of similar neuronal loss.
Keyphrases
- cognitive impairment
- end stage renal disease
- cerebral ischemia
- ejection fraction
- prognostic factors
- oxidative stress
- endoplasmic reticulum stress
- chronic kidney disease
- patient reported outcomes
- peritoneal dialysis
- traumatic brain injury
- spinal cord injury
- subarachnoid hemorrhage
- lps induced
- neuropathic pain
- blood brain barrier
- signaling pathway
- brain injury