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Optically stimulated luminescence detectors for dosimetry and LET measurements in light ion beams.

Jeppe Brage ChristensenIván Domingo MuñozNiels BasslerChristina StenglLily BossinMichele TognoSairos SafaiOliver JäkelEduardo Gardenali Yukihara
Published in: Physics in medicine and biology (2023)
Objective : This work investigates the use of Al 2 O 3 :C and Al 2 O 3 :C,Mg optically stimulated luminescence (OSL) detectors to determine both the dose and the radiation quality in light ion beams. The radiation quality is here expressed through either the linear energy transfer (LET) or the closely related metric Q eff , which depends on the particle's speed and effective charge. The derived LET and Q eff values are applied to improve the dosimetry in light ion beams.

 Approach : OSL detectors were irradiated in mono-energetic 1 H-, 4 He-, 12 C-, and 16 O-ion beams. The OSL signal is associated with two emission bands that were separated using a pulsed stimulation technique and subjected to automatic corrections based on reference irradiations. Each emission band was investigated independently for dosimetry, and the ratio of the two emission intensities was parameterized as a function of fluence- and dose-averaged LET, as well as Q eff . The determined radiation quality was subsequently applied to correct the dose for ionization quenching.

 Main results : For both materials, the Q eff determinations in 1 H- and 4 He-ion beams are within 5 % of the Monte Carlo simulated values. Using the determined radiation quality metrics to correct the non-linear (ionization quenched) detector response leads to doses within 2 % of the reference doses. 

 Significance : Al 2 O 3 :C and Al 2 O 3 :C,Mg OSL detectors are applicable for dosimetry and radiation quality estimations in 1 H- and 4 He-ions. Only Al 2 O 3 :C,Mg shows promising results for dosimetry in 12 C-ions. Across both materials and the investigated ions, the estimated Q eff values were less sensitive to the ion type than the estimated LET values. The reduced uncertainties suggest new possibilities for simultaneously estimating the physical and biological dose in particle therapy with OSL detectors.&#xD.
Keyphrases
  • monte carlo
  • energy transfer
  • quantum dots
  • quality improvement
  • mental health
  • stem cells
  • magnetic resonance
  • radiation therapy
  • mesenchymal stem cells
  • high resolution
  • drug induced