Biosynthetic Hypothesis-Guided Discovery and Total Syntheses of PKS-NRPS Hybrid Metabolites from Endophytic Fungus Periconia Species.
Yijun FanDe-Wu ZhangXiaoyu TaoYuanhao WangJimei LiuLi LiJianyuan ZhaoLi-Yan YuYu-Peng HeJun-Gui DaiYefeng TangPublished in: Organic letters (2019)
Guided by our biosynthetic hypothesis, pericoannosins C-F, four new PKS-NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C-D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C-E have also been completed with high efficiency.
Keyphrases
- high efficiency
- ms ms
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- molecular docking
- hiv testing
- small molecule
- electronic health record
- hiv aids
- high resolution
- high throughput
- big data
- single cell
- men who have sex with men
- mass spectrometry
- south africa
- genetic diversity
- molecular dynamics simulations