Cancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life of patients. This review article comprehensively examines nutritional therapy strategies that specifically address tumor energy metabolism. Moreover, it explores the intricate interplay between energy metabolism and the gut microbiota in the context of nutritional therapy. The findings aim to provide valuable insights for future clinical research endeavors in this field.
Keyphrases
- clinical trial
- end stage renal disease
- radiation therapy
- mesenchymal stem cells
- newly diagnosed
- cardiovascular disease
- type diabetes
- risk factors
- peritoneal dialysis
- adipose tissue
- risk assessment
- blood pressure
- locally advanced
- current status
- drug delivery
- prognostic factors
- rectal cancer
- climate change
- replacement therapy
- childhood cancer
- human health
- case control
- patient reported