Anti-inflammatory Effects of Pelargonium endlicherianum Fenzl. Extracts in Lipopolysaccharide-stimulated Macrophages.

Ahmet Cumaoğlu Gökçe Şeker Karatoprak Mükerrem Betül Aycan Müberra Koşar

Published in: Turkish journal of pharmaceutical sciences (2018)

Our data indicate that especially 11% ethanol root extract of P. endlicherianum targets the inflammatory response of macrophages via inhibition of COX-2, IL-6, and TNF-α through inactivation of the NF-κB signalling pathway, supporting the pharmacologic basis of P. endlicherianum as a traditional herbal medicine for the treatment of inflammation and its associated disorders.

Keyphrases

inflammatory response
lps induced
oxidative stress
toll like receptor
lipopolysaccharide induced
rheumatoid arthritis
signaling pathway
electronic health record
nuclear factor
data analysis
immune response
artificial intelligence