TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signalling.
Pierre-Marie BoutanquoiOlivier BurgyGuillaume BeltramoPierre-Simon BellayeLucile DondaineGuillaume MarcionLenny PommerolleAurélie VadelMaximilien SpanjaardOleg N DemidovArnaud A MailleuxBruno CrestaniMartin R J KolbCarmen GarridoFrançoise GoirandPhilippe BonniaudPublished in: The European respiratory journal (2020)
Our results demonstrate a key role of TRIM33 as a negative regulator of lung fibrosis. Since TRIM33 directly associates with HSPB5, which impairs its activity, inhibitors of TRIM33/HSPB5 interaction may be of interest in the treatment of IPF.