Pharmacokinetics of perioperative FVIII in adult patients with haemophilia A: An external validation and development of an alternative population pharmacokinetic model.

Jing 'Daisy' Zhu Yi Shuan Shirley Wu Ryan J Beechinor Ryan M Kemper Laura H Bukkems Ron A A Mathot Marjon H Cnossen Daniel Gonzalez Sheh-Li Chen Nigel S Key Daniel J Crona

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2021)

External validation revealed a previously published popPK model of FVIII did not adequately characterize UNC patients, likely due to differences in patient populations. Future prospective studies are needed to evaluate our model prior to implementation into clinical practice.

Keyphrases

end stage renal disease
clinical practice
healthcare
newly diagnosed
primary care
chronic kidney disease
prognostic factors
peritoneal dialysis
current status
patient reported