Auricular Vagus Nerve Stimulation Mitigates Inflammation and Vasospasm in Subarachnoid Hemorrhage: A Randomized Trial.
Anna L HuguenardGansheng TanDennis J RivetFeng GaoGabrielle W JohnsonMarkus AdamekAndrew T CoxonTerrance T KummerJoshua W OsbunAnanth K VellimanaDavid D LimbrickGregory J ZipfelPeter BrunnerEric C LeuthardtPublished in: medRxiv : the preprint server for health sciences (2024)
taVNS is a non-invasive method of neuro- and systemic immunomodulation. This trial supports that taVNS following SAH can mitigate the inflammatory response, reduce radiographic vasospasm, and potentially improve functional and neurological outcomes. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04557618.
Keyphrases
- subarachnoid hemorrhage
- clinical trial
- inflammatory response
- cerebral ischemia
- brain injury
- phase ii
- phase iii
- study protocol
- oxidative stress
- lipopolysaccharide induced
- open label
- computed tomography
- image quality
- dual energy
- lps induced
- contrast enhanced
- toll like receptor
- double blind
- positron emission tomography
- radiation induced
- adipose tissue
- metabolic syndrome
- pet ct