An Ultrasensitive Routine LC-MS/MS Method for Estradiol and Estrone in the Clinically Relevant Sub-Picomolar Range.
Bjørn-Erik BertelsenRalf KellmannKristin VisteAnne Turid BjørnevikHans Petter EikesdalPer Eystein LønningGunnar MellgrenBjørg AlmåsPublished in: Journal of the Endocrine Society (2020)
We report an ultrasensitive LCMS/MS routine assay that measures pretreatment and suppressed levels of estradiol/estrone during aromatase inhibitor treatment of postmenopausal breast cancer patients.
Keyphrases
- gold nanoparticles
- clinical practice
- quantum dots
- mass spectrometry
- estrogen receptor
- multiple sclerosis
- molecularly imprinted
- label free
- high throughput
- bone mineral density
- simultaneous determination
- single cell
- solid phase extraction
- breast cancer risk
- smoking cessation
- replacement therapy
- tandem mass spectrometry