Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats.

Andrey V ElchaninovTimur Kh FatkhudinovNatalia Y UsmanEvgeniya Y KananykhinaIrina V ArutyunyanAndrey V MakarovAnastasia V LokhoninaIrina Z EreminaViktor V SurovtsevDmitry V GoldshteinGalina B BolshakovaValeria V GlinkinaGennady T Sukhikh

Published in: BMC immunology (2018)

The delayed onset of hepatocyte proliferation correlates with low levels of Tnfα in the residual hepatic tissue. The observed growth inhibition possibly reflects specific composition of macrophage population of the liver. It is entirely composed of embryonically-derived Kupffer cells, which express the 'proregeneratory' M2 macrophage-specific marker CD206 in the course of regeneration.

Keyphrases

adipose tissue
induced apoptosis
stem cells
signaling pathway
rheumatoid arthritis
endoplasmic reticulum stress
liver injury
cell death
drug induced