Autophagy Primes Neutrophils for Neutrophil Extracellular Trap Formation during Sepsis.

So Young ParkSanjeeb ShresthaYoung-Jin YounJun-Kyu KimShin-Yeong KimHyun Jung KimSo-Hee ParkWon-Gyun AhnShin KimMyung Goo LeeKi-Suck JungYong Bum ParkEun-Kyung MoYousang KoSuh-Young LeeYounsuck KohMyung Jae ParkDong-Keun SongChang-Won Hong

Published in: American journal of respiratory and critical care medicine (2017)

These results indicate that neutrophil autophagy primes neutrophils for increased NET formation, which is important for proper neutrophil effector functions during sepsis. Our study provides important insights into the role of autophagy in neutrophils during sepsis.

Keyphrases

cell death
septic shock
endoplasmic reticulum stress
acute kidney injury
intensive care unit
signaling pathway
oxidative stress
dendritic cells
immune response