The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis.

Jemima SeidenbergMara StellatoAmela HukaraBurkhard LudewigKarin KlingelOliver DistlerPrzemysław Błyszczuk Gabriela Kania

Published in: International journal of molecular sciences (2021)

Our findings demonstrate that Fosl-2 regulates autophagocytosis and the TGF-β-Fosl-2-autophagy axis controls differentiation of cardiac fibroblasts. These data provide a new insight for the development of pharmaceutical targets in cardiac fibrosis.

Keyphrases

left ventricular
transcription factor
cell death
endoplasmic reticulum stress
signaling pathway
extracellular matrix
heart failure
transforming growth factor
electronic health record
machine learning
big data
epithelial mesenchymal transition
dna binding
deep learning
atrial fibrillation