Pharmacological therapies for the management of fistulising Crohn's disease: A systematic review and meta-analysis.

Sudheer Kumar VuyyuruVirginia SolitanoNeeraj Narula Matthew James LeeJohn K MacDonaldJeffrey D McCurdySiddharth SinghChristopher Ma Vipul Jairath

Published in: Journal of Crohn's & colitis (2023)

Very low-to-moderate certainty evidence suggests that anti-TNF therapy, oral small molecules, ustekinumab, and MSCs are effective for perianal fistulising CD. Dedicated fistula studies evaluating biologics and small molecules are needed.

Keyphrases

mesenchymal stem cells
rheumatoid arthritis
high intensity
case control
umbilical cord
nk cells
smoking cessation