Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors.

Stella KoutrosNina RaoLee E MooreMichael L NickersonDonghyuk LeeBin ZhuLarissa A PardoDalsu BarisMolly SchwennAlison JohnsonKristine JonesMontserrat Garcia-Closas Ludmila Prokunina-OlssonDebra T SilvermanNathaniel RothmanMichael Dean

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

These data quantify the contribution of bladder cancer risk factors to mutational burden and suggest different signature enrichments among never, former, and current smokers.

Keyphrases

risk factors
papillary thyroid
spinal cord injury
electronic health record
smoking cessation
squamous cell
single cell
cancer therapy
genome wide
squamous cell carcinoma
childhood cancer
lymph node metastasis
dna methylation
deep learning
urinary tract