Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.
Qibin QiA Heather EliassenBing YuJee-Young MoonJin C ChaiRuth J F LoosJie HuMiguel Ruiz-CanelaCasey RebholzZheng WangMykhaylo UsykGuo-Chong ChenBianca C PornealaWenshuang WangNgoc Quynh NguyenElena V FeofanovaMegan L GroveThomas J WangRobert E GersztenJosée DupuisJordi Salas-SalvadóWei BaoDavid L PerkinsMartha L DaviglusBharat ThyagarajanJianwen CaiTao WangJoAnn E MansonMiguel A Martínez-GonzálezElizabeth SelvinKathryn M RexrodeClary B ClishFrank B HuJames B MeigsRob KnightRobert D BurkEric BoerwinkleRobert C KaplanPublished in: Gut (2021)
Higher milk intake among lactase non-persistent individuals, and higher fibre intake were associated with a favourable profile of circulating tryptophan metabolites for T2D, potentially through the host-microbial cross-talk shifting tryptophan metabolism toward gut microbial indolepropionate production.