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A Bayesian data fusion based approach for learning genome-wide transcriptional regulatory networks.

Elisabetta SautaAndrea DemartiniFrancesca VitaliAlberto RivaRiccardo Bellazzi
Published in: BMC bioinformatics (2020)
This Bayesian omics-data fusion based methodology allows to gain a genome-wide picture of the transcriptional interplay, helping to unravel key hierarchical transcriptional interactions, which could be subsequently investigated, and it represents a promising learning approach suitable for multi-layered genomic data integration, given its robustness to noisy sources and its tailored framework for handling high dimensional data.
Keyphrases
  • genome wide
  • electronic health record
  • transcription factor
  • big data
  • gene expression
  • dna methylation
  • copy number
  • heat shock
  • mass spectrometry
  • single cell
  • deep learning
  • high speed