Stem Cells and Their Derivatives: Unlocking the Promising Potential of Minimally Manipulated Cells for In Situ Tissue Engineering.
Ilya D KlabukovDenis BaranovskiiPublished in: Cell transplantation (2024)
We've read with great interest the article by Smolinska et al. entitled "Stem Cells and Their Derivatives: An Implication for the Regeneration of Nonunion Fractures" regarding the recent scientific studies dealing with the treatment of nonunion fractures in clinical and preclinical settings using Mesenchymal Stem Cell (MSC)-based therapeutic techniques. Bone tissue regeneration is a dynamic process that involves the restoration of damaged or lost bone structure and function. Traditional approaches such as autografts and allografts, platelet rich plasma (PRP) treatment and cell therapies, have limitations, including donor site morbidity and immunologic concerns, as well as cell culture and processing requirements. In contrast, the use of minimally manipulated cells that do not require culturing has emerged as a promising alternative that offers several advantages in bone tissue regeneration.
Keyphrases
- stem cells
- platelet rich plasma
- cell therapy
- induced apoptosis
- bone mineral density
- tissue engineering
- cell cycle arrest
- mesenchymal stem cells
- soft tissue
- magnetic resonance
- bone loss
- oxidative stress
- single cell
- endoplasmic reticulum stress
- bone regeneration
- signaling pathway
- body composition
- risk assessment
- cell proliferation
- bone marrow
- computed tomography
- single molecule
- pi k akt