Therapy-Acquired Clonal Mutations in Thiopurine Drug-Response Genes Drive Majority of Early Relapses in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.
Rozy ThakurPrateek BhatiaMinu SinghSreejesh SreedharanunniPankaj SharmaAditya SinghAmita TrehanPublished in: Diagnostics (Basel, Switzerland) (2023)
Our study highlights the high frequency of early relapses driven by TA clones, demonstrating the need to identify their early rise during chemotherapy by digital PCR.
Keyphrases
- high frequency
- acute lymphoblastic leukemia
- transcranial magnetic stimulation
- squamous cell carcinoma
- stem cells
- gene expression
- mesenchymal stem cells
- allogeneic hematopoietic stem cell transplantation
- locally advanced
- young adults
- bone marrow
- drug induced
- replacement therapy
- bioinformatics analysis
- patients with inflammatory bowel disease