Genistein prevents the decrease in ganglioside levels induced by amyloid-beta in the frontal cortex of rats.
Fernanda Dos Santos PetryJuliana Bender HoppeCaroline Peres KleinBernardo Gindri Dos SantosRégis Mateus HözerChristianne Gazzana SalbegoVera Maria Treis TrindadePublished in: Neurological research (2022)
Considering the roles of gangliosides on neuronal function, findings described here can contribute to the knowledge of the potential neuroprotective mechanisms of genistein against Aβ-induced alterations in the frontal cortex of rats and provide a novel view in the multifaceted scenario associated with its beneficial effects.