Increased cochlear radiation dose predicts delayed hearing loss following both stereotactic radiosurgery and fractionated stereotactic radiotherapy for vestibular schwannoma.

Kunal S PatelEdwin NgTaranjit KaurTyler MiaoTania KaprealianPercy LeeNader PouratianMichael T SelchAntonio A F De SallesQuinton GopenStephen TennIsaac Yang

Published in: Journal of neuro-oncology (2019)

Our data suggests the minimal dose of radiation that the cochlear volume is exposed to is a predictor of delayed hearing loss after either SRS or fSRT. A threshold of 5 Gy/35 Gy may lead to improved hearing preservation after radiotherapy. Further prospective multi center studies can further elucidate this mechanism.

Keyphrases

hearing loss
early stage
radiation induced
locally advanced
radiation therapy
brain metastases
electronic health record
small cell lung cancer
rectal cancer
big data
case control
machine learning
deep learning
data analysis