Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases.

Valentin RauschAndreas KriegJordi CampsBianca BehrensManfred BeierDarawalee WangsaKerstin Heselmeyer-HaddadStephan E BaldusWolfram T KnoefelThomas RiedNikolas H Stoecklein

Published in: BMC research notes (2017)

Pancreatic cancers show a high degree of intratumor heterogeneity, which could lead to resistance of chemotherapy and worse outcome. ACGH analysis reveals regions preferentially gained or lost in synchronous metastases encoding for genes involved in cancer-related pathways, which could lead to novel therapeutic opportunities.

Keyphrases

bone marrow
single cell
high resolution
high throughput
copy number
single molecule
platelet rich plasma
nucleic acid
dna methylation
genome wide