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Xp11 translocation renal cell carcinoma with morphological features mimicking multilocular cystic renal neoplasm of low malignant potential: a series of six cases with molecular analysis.

Yankun SongXiaoxue YinQiuyuan XiaLinmao ZhengJin YaoHao ZengLing NieJing GongQiao ZhouNi Chen
Published in: Journal of clinical pathology (2020)
Here, we introduce a relatively inertia-variant of Xp11 translocation RCC which mimics MCRN-LMP. The distinctive morphological condition is linked to MED15-TFE3 gene fusion. In fact, renal neoplasms with morphological features of MCRN-LMP, especially those containing psammoma bodies, should be routinely evaluated for evidence of TFE3 gene rearrangements.
Keyphrases
  • renal cell carcinoma
  • epstein barr virus
  • copy number
  • genome wide
  • low grade
  • gene expression
  • dna methylation
  • diffuse large b cell lymphoma
  • risk assessment
  • climate change