EmPHasis-10 health-related quality of life score predicts outcomes in patients with idiopathic and connective tissue disease-associated pulmonary arterial hypertension: results from a UK multicentre study.
Robert A LewisIain ArmstrongCarmel BergbaumMelanie J BrewisJohn CannonAthanasios CharalampopoulosA Colin ChurchJ Gerry CoghlanRachel J DaviesKonstantinos DimopoulosCharlie ElliotJ Simon R GibbsWendy Gin-SingGulam HajiAbdul G HameedLuke S HowardMartin K JohnsonAleksander KempnyDavid G KielyFrancesco Lo GiudiceColm McCabeAndrew J PeacockOyinkansola PeleyejuJoanna Pepke-ZabaGary PolwarthLaura C PriceIan SabroeBenjamin E SchreiberKaren ShearesDolores TaboadaAlfred Arthur Roger ThompsonMark R ToshnerIvy WanjikuS John WortJanelle YorkeRobin CondliffePublished in: The European respiratory journal (2021)
Health-related quality of life (HRQoL) scores assess symptom burden in pulmonary arterial hypertension (PAH) but data regarding their role in prognostication and risk stratification are limited. We assessed these relationships using the emPHasis-10 HRQoL measure.1745 patients with idiopathic PAH (IPAH), drug-induced PAH (DPAH), heritable PAH (HPAH) (collectively "(I/D/H)PAH"), or connective tissue disease-associated PAH (CTD-PAH), who had completed emPHasis-10 questionnaires at one of six UK referral centres between 2014 and 2017, were identified. Correlations with exercise capacity and World Health Organization (WHO) functional class were assessed, and exploratory risk stratification thresholds were tested.Moderate correlations were seen between emPHasis-10 scores and 6-min walk distance (r=-0.546), incremental shuttle walk distance (r=-0.504) and WHO functional class (r=0.497) (all p<0.0001). Distribution of emPHasis-10 score differed significantly between each WHO functional class (all p<0.0001). On multivariate analysis, emPHasis-10 score, but not WHO functional class, was an independent predictor of mortality. In a risk stratification approach, scores of 0-16, 17-33 and 34-50 identified incident patients with 1-year mortality of 5%, 10% and 23%, respectively. Survival of patients in WHO functional class III could be further stratified using an emPHasis-10 score ≥34 (p<0.01). At follow-up, patients with improved emPHasis-10 scores had improved exercise capacity (p<0.0001) and patients who transitioned between risk groups demonstrated similar survival to patients originally in those risk groups.The emPHasis-10 score is an independent prognostic marker in patients with (I/D/H)PAH or CTD-PAH. It has utility in risk stratification in addition to currently used parameters. Improvement in emPHasis-10 score is associated with improved exercise capacity.
Keyphrases
- pulmonary arterial hypertension
- polycyclic aromatic hydrocarbons
- end stage renal disease
- drug induced
- pulmonary hypertension
- high intensity
- chronic kidney disease
- pulmonary artery
- ejection fraction
- newly diagnosed
- liver injury
- primary care
- peritoneal dialysis
- risk factors
- resistance training
- coronary artery disease
- electronic health record
- body composition
- data analysis
- deep learning