Precise positioning of gamma ray interactions in multiplexed pixelated scintillators using artificial neural networks.

Introduction . The positioning of γ ray interactions in positron emission tomography (PET) detectors is commonly made through the evaluation of the Anger logic flood histograms. machine learning techniques, leveraging features extracted from signal waveform, have demonstrated successful applications in addressing various challenges in PET instrumentation. Aim . This paper evaluates the use of artificial neural networks (NN) for γ ray interaction positioning in pixelated scintillators coupled to a multiplexed array of silicon photomultipliers (SiPM). Methods . An array of 16 Cerium doped Lutetium-based (LYSO) crystal pixels (cross-section 2 × 2 mm 2 ) coupled to 16 SiPM (S13360-1350) were used for the experimental setup. Data from each of the 16 LYSO pixels was recorded, a total of 160000 events. The detectors were irradiated by 511 keV annihilation γ rays from a Sodium-22 ( 22 Na) source. Another LYSO crystal was used for electronic collimation. Features extracted from the signal waveform were used to train the model. Two models were tested: i) single multiple-class neural network (mcNN), with 16 possible outputs followed by a softmax and ii) 16 binary classification neural networks (bNN), each one specialized in identifying events occurred in each position. Results . Both NN models showed a mean positioning accuracy above 85% on the evaluation dataset, although the mcNN is faster to train. Discussion The method's accuracy is affected by the introduction of misclassified events that interacted in the neighbour's crystals and were misclassified during the dataset acquisition. Electronic collimation reduces this effect, however results could be improved using a more complex acquisition setup, such as a light-sharing configuration. Conclusions The methods comparison showed that mcNN and bNN can surpass the Anger logic, showing the feasibility of using these models in positioning procedures of future multiplexed detector systems in a linear configuration.