Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression.

Chia-Hung Hsu Hon-Ping Ma Jiann Ruey Ong Ming-Shou Hsieh Vijesh Kumar Yadav Chi-Tai Yeh Tsu-Yi Chao Wei-Hwa Lee Wen-Chien Huang Kuang-Tai Kuo Iat-Hang Fong Chih-Cheng Lin Chih-Ming Su

Published in: Disease markers (2022)

Our results revealed that CBFB may promote bone metastasis in patients with breast cancer. Of therapeutic relevance, targeting CBFB resulted in decreased tumor burden and bone metastasis, downregulation of bone metastasis markers, and impaired regulation of oxidative stress-related proteins NAE1 and NOS1.

Keyphrases

body composition
bone mineral density
oxidative stress
bone loss
dna damage
bone regeneration
postmenopausal women
signaling pathway
induced apoptosis
young adults
cancer therapy
drug delivery
endoplasmic reticulum stress
nitric oxide
drug induced